The New York Yankees (40-26) are set to pursue a three-game sweep against the Cleveland Guardians (37-32) on Wednesday, June 10. Having secured victories in the first two games of the series, including a 7-5 extra-innings thriller on Monday and a close 3-2 win on Tuesday, the Yankees are on a strong run, winning six of their last seven games overall.

Parker Messick (6-2, 2.40 ERA) will take the mound for the Guardians, while the Yankees will counter with Carlos Rodon (1-2, 2.88 ERA). Currently, New York leads the season series 3-2 in 2026.

First pitch is scheduled for 1:10 p.m. ET at Progressive Field in Cleveland. The Guardians are favored at -116 on the money line, suggesting a risk of $116 to win $100, while the over/under for total runs is set at 7.5.

Before placing any bets, it’s essential to consider the insights from SportsLine's proven computer model, which has successfully simulated this matchup 10,000 times. The model is currently on a hot streak with a 19-7 record on top-rated MLB picks and has previously excelled in home run prop bets, yielding nearly 30 units of profit in 2025.

Key betting information includes:

• Yankees vs Guardians money line: Yankees -103, Guardians -116
• Over/under: 7.5 runs
• Run line: Guardians -1.5 (+167)

Top predictions from the model indicate:

• The total runs are likely to go over 7.5 combined.
• The model forecasts three Yankees players to exceed 1.6 total bases, with Cody Bellinger projected at 1.86 total bases.
• For the Guardians, only Jose Ramirez is expected to surpass 1.6 total bases.

With an expected combined total of 9.5 runs, the over hits 68% of the time in similar matchups. For the best money-line pick, follow the insights from SportsLine.