A crucial spot in the American League Championship Series is on the line as the Chicago White Sox face off against the Cleveland Guardians in Game 5 of the ALDS on Saturday night. After Cleveland leveled the series with a 9-5 victory on Thursday, the tension is high.

The White Sox (84-78), who ended the regular season second in the AL Central, struggle away from home with a 38-45 record in 2026, including postseason play. In contrast, the Guardians (85-77), division winners, hold a 41-42 home record. The matchup features Sean Burke (11-7, 3.34 ERA) for Chicago and Gavin Williams (14-8, 3.76 ERA) for Cleveland.

First pitch is scheduled for 8 p.m. ET at Progressive Field in Cleveland. The White Sox have a narrow edge in their season series against the Guardians, going 9-8 in both regular and postseason matchups. Cleveland enters as a -142 favorite on the money line, with Chicago at +119 and the over/under set at 7.5 runs. The Over has hit in six of the last seven encounters between these teams.

SportsLine's model, which simulates every MLB game 10,000 times, has produced a 31-25 record on top-rated MLB money-line picks, yielding over $900 in returns for $100 players. The model predicts that the game will surpass 7.5 combined runs, given that both teams are projected to score over 4.0 runs on average, ultimately combining for 8.5 total runs.

For detailed picks and predictions, visit SportsLine for insights on the White Sox vs. Guardians matchup.