Week 5 of the NFL brings exciting divisional matchups that could shape the season. In particular, the Seahawks vs. 49ers game stands out. Seattle has a notable scoring trend, having scored exactly 13 points in four of their last seven meetings against San Francisco. This pattern could guide bettors looking to make accurate score predictions.

Other key matchups include:

• Packers vs. Bears (-3)
• Texans vs. Titans (+7)
• Giants vs. Commanders (-3.5)
• Broncos vs. Chargers (+3.5)

The Green Bay Packers enter as home underdogs against the Chicago Bears for the first time in 20 years, with Caleb Williams (hamstring) likely missing another game.

Eric Cohen, a SportsLine expert, has meticulously analyzed the Week 5 slate, boasting an impressive record of 188-96-1 (66%) for the 2025-26 season and 38-26 (59%) for the current season. Following his predictions could yield strong betting returns.

Among his top picks, Cohen highlights the Texans (-7, 38.5) to secure a win against the Titans. Despite the Titans' recent defensive improvements, their offense ranks at the bottom in total yards and points scored. Houston’s offense has thrived with Nico Collins healthy, scoring over 30 points in two games. Cohen anticipates a low-scoring affair, predicting Texans 22, Titans 13.

Cohen also identifies eight games where the team with the worse record prevails, crucial for making profitable Week 5 bets. For those looking to refine their NFL betting strategies, his precise predictions and insights are available exclusively at SportsLine.