The Week 5 NFL schedule features a limited number of matchups, with only one game between teams above .500: Seahawks vs. 49ers. Seattle enters as a 3-point favorite at home. Meanwhile, several games involve teams still seeking their first wins, including Texans vs. Titans (+6.5) and Steelers vs. Colts (+2.5). The Bengals face the Dolphins as Miami is a significant underdog, with a 7-point spread.

Colts vs. Steelers presents a close spread, with Indianapolis returning from London and Pittsburgh benefiting from a mini-bye after a Thursday game. This week's games mark the first with byes, allowing bettors to focus on fewer matchups.

SportsLine's advanced computer model, which has successfully simulated each NFL game 10,000 times, has provided valuable betting insights. Since its launch, the model has yielded over $7,000 in profits for $100 bettors, boasting a 55-44 record on top-rated picks since 2024.

Top Week 5 Predictions

• Vikings (-1.5, 42.5) are expected to cover against the Saints. New Orleans struggles as a home underdog, holding a 1-5 ATS record in their last six such games. The Vikings, on a nine-game win streak, excel with a top-tier scoring defense, covering over 60% of the time.

• Bengals (-7.5, 42.5) are predicted to cover against the Dolphins, who rank last in scoring. Miami has faltered without De'Von Achane, struggling in their last outing with lows in points and total yards. Joe Burrow leads a strong passing offense against the Dolphins' defense, with the model forecasting 47 total points, hitting the Over nearly 60% of the time.

For a comprehensive look at all Week 5 matchups and betting advice, visit SportsLine to see the model's complete predictions and A-rated spread picks.