As Week 4 of the NFL season approaches, 16 games are on the betting slate before byes begin in Week 5. Notably, the league heads to London for a matchup between the Colts and Commanders, with Indy favored by 3 points. Other key games include Patriots vs. Bills (-6.5) and Chiefs vs. Raiders (+4.5) on Sunday, while Monday features a special anniversary game where the Saints are 2.5-point favorites over the Falcons in honor of the 20th anniversary of the "Domecoming" in New Orleans.

For those considering heavy favorites this week, the Ravens stand out as 11.5-point favorites against the winless Titans, while the Vikings are favored by 10 points over 0-3 Miami. SportsLine's advanced computer model, which has shown impressive results, has locked in betting picks for every matchup this week.

Top Week 4 NFL Predictions

• Giants (+1, 44.5) are expected to cover against the Cardinals. Arizona's early season win is losing luster as they face back-to-back losses, while the Giants excel in time of possession and field position. The model forecasts New York winning straight up nearly 60% of the time.

• Seahawks (-6.5, 43.5) are predicted to cover against the Chargers. After a disappointing loss despite forcing turnovers, L.A. faces a determined Seattle squad eager to rebound after a recent loss. The model suggests Seattle covers the spread in over 60% of simulations.

The model has also made predictions on every game this week, revealing five teams projected to win by double digits. For comprehensive betting guidance and to see the full list of picks, visit SportsLine.