The Week 1 NFL schedule has commenced with a couple of games already played, but 14 more await on Sunday and Monday, featuring potential playoff previews. Key matchups include:

• Ravens vs. Colts (+3.5)
• Chiefs vs. Broncos (-2.5)
• Bills vs. Texans (+1.5)
• Packers vs. Vikings (-1.5)

The highest total this week is 50.5 in the Buccaneers vs. Bengals game, while the lowest is 38.5 in the Titans vs. Jets, marking the debut of new Tennessee head coach Robert Saleh against the team that released him in 2024.

Before placing any bets, it’s essential to check the exact Week 1 NFL score predictions from SportsLine’s proven model, which has successfully simulated every NFL game 10,000 times. This model has generated over $7,000 for $100 players on top-rated NFL picks since its inception and holds a 53-37 record on top-rated picks dating back to 2024.

For Week 1, the model strongly backs the Philadelphia Eagles (-5.5) to defeat the Washington Commanders, predicting a score of 28-18. Recent history favors the Eagles, who have won seven of the last 10 meetings against the Commanders. Washington struggles, having lost eight of their last 10 games overall.

Key player projections include:

• Jalen Hurts (Eagles): 213 yards, 1.79 touchdowns
• Saquon Barkley (Eagles): nearly 100 yards rushing, 1 touchdown
• DeVonta Smith (Eagles): five receptions, nearly 75 yards
• Jayden Daniels (Commanders): 175+ yards passing, 1 touchdown
• Jacory Croskey-Merritt (Commanders): nearly 50 yards rushing

The model also indicates that Philadelphia covers 60% of the time, with the Over hitting by 1.5 points. For more insights and predictions, visit SportsLine to view the complete list of Week 1 NFL score forecasts.