The NFL kicks off its season with a thrilling lineup in Week 1, featuring matchups that promise excitement and intrigue. Among the highlight games are divisional battles like Chiefs vs. Broncos (+2.5) and Cowboys vs. Giants (+3), alongside Aaron Rodgers' anticipated appearance in Steelers vs. Falcons (+4.5). A less publicized yet interesting matchup includes Dolphins vs. Raiders, showcasing new starters for both teams.

Miami's Malik Willis will face off against Kirk Cousins, who earns the starting position over Fernando Mendoza. The Raiders, who finished last season with a 7-10 ATS record, enter as a 3-point favorite according to the latest odds. SportsLine's advanced computer model, which has proven profitable for its followers, now focuses on Week 1 betting predictions.

Top Predictions for Week 1

• Jaguars (-8.5, 40) are projected to cover at home against Cleveland in their Sunday 1 p.m. ET kickoff. The model indicates that Jacksonville has a strong chance of covering the spread, reflecting their impressive 12-5 ATS record from the previous season, particularly excelling at home.

• Eagles (-5.5, 44.5) are forecasted to cover against the Commanders at 4:25 p.m. ET. Jalen Hurts has dominated Washington, winning eight of his last nine starts against them. With Washington's defense struggling and dealing with injuries, Philadelphia stands a solid chance, with a 60% likelihood of covering the spread according to simulations.

The model also highlights several underdogs poised for potential upsets, making it an essential resource for bettors looking to maximize their Week 1 picks. For detailed predictions and insights on every matchup, SportsLine provides comprehensive betting advice.