The NFL opens its season with thrilling matchups, and Week 1 is packed with excitement. Key games include Packers vs. Vikings (+1.5) and Cowboys vs. Giants (+2.5). Notably, the Steelers vs. Falcons (+3) features Aaron Rodgers in what could be his final season. Among these, the Dolphins vs. Raiders matchup stands out for its new quarterbacks: Malik Willis for Miami and Kirk Cousins for Las Vegas, with the Raiders favored by 3.5 points.

SportsLine's advanced computer model, which simulates each game 10,000 times, has a successful track record, boasting over $7,000 in returns for $100 players since its inception. As it approaches the 2026 NFL season, the model holds a 53-37 record on top-rated picks since 2024.

Top Predictions for Week 1:

• Jaguars (-7.5) vs. Browns: The model predicts the Jaguars will cover, supported by their 12-5 ATS record last season. Trevor Lawrence is expected to throw for over 200 yards and two touchdowns against a depleted Browns defense.

• Eagles (-4.5) vs. Commanders: The model backs the Eagles, citing Jalen Hurts' impressive record against Washington, winning eight of nine starts. The Commanders struggled defensively last year, providing the Eagles with a significant edge.

With these insights, bettors can confidently make selections for the opening week. The model also highlights potential underdogs that could upset the odds, promising a thrilling start to the NFL season.