Preseason football enthusiasts are in for a treat as the NFL kicks off with six Week 1 games on Thursday. The highlight of the day features the San Francisco 49ers hosting the Tennessee Titans at Levi's Stadium in Santa Clara, California.

This matchup marks the debut of Robert Saleh as the Titans' head coach, who previously served as the 49ers' defensive coordinator. Meanwhile, Kyle Shanahan, the 49ers' coach, is set to watch from the sidelines as he recovers from a concussion.

Key Game Details:

• Matchup: Titans vs. 49ers
• Time: 9 p.m.
• Location: Santa Clara, Calif.
• TV: NFL Network
• Betting Line: Titans -6

Despite the Titans' struggles last season, finishing with a 3-14 record, they are favored in this game. Notably, Saleh has an impressive preseason record of 10-2-1 as a head coach. SportsLine expert Larry Hartstein highlights that the Titans are focusing heavily on this game, with starting quarterback Cam Ward expected to play.

In addition to the NFL action, the MLB offers a rich slate of games, including:

• Cubs at Nationals

  • Time: 4:05 p.m.
  • Pick: Nationals +1.5

• Phillies at Twins

  • Time: 7:30 p.m.
  • Pick: Twins +1.5

• Rangers at Angels

  • Time: 10:07 p.m.
  • Pick: Angels +1.5

• Brewers at Dodgers

  • Time: 10:10 p.m.
  • Pick: Brewers +129

As fans gear up for an exciting day of sports, the 49ers vs. Titans game stands out as a key event in the NFL preseason, while the MLB contests add to the thrill of sports betting.