San Francisco 49ers quarterback Brock Purdy is making history in the 2026 season, leading his team to a 4-0 start without a single sack, fumble, or interception. His exceptional performance includes:

• Passer rating: 126.2 (NFL leader)
• Passing success rate: 61.9%
• Expected points added (EPA) per dropback: 0.53
• Passing touchdowns: 11 (tied for league lead)

Despite this success, Purdy faces a formidable challenge in Week 5 against the Seattle Seahawks, who boast the league's top defense. The Seahawks have allowed just 4.0 yards per play this season, showcasing their defensive prowess under head coach Mike Macdonald. In their last two meetings, Seattle dominated, including a 41-6 playoff victory in January.

Purdy's success hinges on his ability to navigate early downs, where he leads the NFL in EPA per dropback. However, the Seahawks' defense creates pressure at a high rate without heavy blitzing, relying on their front four to disrupt opposing quarterbacks.

Key players on Seattle's defensive line include:

• Uchenna Nwosu (22.2% early down pressure rate)
• DeMarcus Lawrence (15.5% early down pressure rate)
• Leonard Williams (14.8% early down pressure rate)

The 49ers' offensive line, led by 12-time Pro Bowl tackle Trent Williams, must perform at its best to protect Purdy. Williams has faced increased pressure from the Seahawks' defense, which has historically challenged him.

As the two teams prepare for their matchup at Lumen Field, the tactical battle between Purdy and Shanahan versus Macdonald's defense promises to be a highlight of the weekend. With high stakes on the line, will Purdy finally overcome the Seahawks' defense?