As Week 4 of the NFL season approaches, two teams with Super Bowl ambitions are eager to secure their first wins. On Sunday, the Houston Texans aim to notch their first victory against the Dallas Cowboys (+2.5), while the Los Angeles Chargers look to overcome the Seattle Seahawks (-7) in Seattle.

The highest over/under for the Sunday slate features an intriguing AFC clash between the Jacksonville Jaguars and the Cincinnati Bengals (O/U 51.5) at Cincinnati. The week wraps up with a crucial Monday Night Football showdown, pitting the Atlanta Falcons against the New Orleans Saints (-2.5). The Falcons are riding high after a 35-14 victory over the Green Bay Packers, while the Saints are looking to rebound from a close 35-27 loss to the Las Vegas Raiders.

Before placing any bets, it's essential to consider the predictions powered by SportsLine's self-learning AI. This technology analyzes historical data and evaluates team matchups, providing insights into betting lines and potential outcomes.

Top Week 4 NFL AI Picks

• Cardinals vs. Giants: SportsLine AI forecasts a narrow 21-19 win for the Arizona Cardinals against the New York Giants. After starting strong with a 26-14 win over the Chargers, the Cardinals have faced setbacks, including a 36-30 loss to the San Francisco 49ers. Quarterback Jacoby Brissett performed well in that loss, completing 38 of 52 passes for 280 yards and two touchdowns.

• The Giants, now at 2-1, managed a 12-7 victory over Tennessee but face challenges ahead. With starting quarterback Jaxson Dart out for the season, they traded for J.J. McCarthy but will start Jameis Winston, who has a 51% completion rate this season.

SportsLine AI also suggests the Under (44.5) for the Cardinals vs. Giants game as a B-level pick, with Arizona favored at -1.5 for ATS bets.

For comprehensive predictions and insights on all 16 Week 4 matchups, consult SportsLine's AI-generated picks before making your bets.