The 2026-27 UEFA Champions League kicks off on Tuesday with a highly anticipated match between Real Madrid and Inter Milan at the Santiago Bernabéu in Madrid, Spain, starting at 3 p.m. ET. This meeting marks the first encounter between the two clubs since 2021.

Real Madrid, the record 15-time UCL champion, aims to bounce back after their quarterfinal exit last year, while Inter Milan, with three Champions League titles, seeks redemption following their elimination in the 2026 knockout round playoffs. Last season, Inter clinched the Serie A title, while Madrid finished second in La Liga.

In terms of betting odds, Real Madrid enters as the -155 favorites, with Inter Milan listed as the +380 underdogs. A draw stands at +340, and the over/under for total goals is set at 3.5.

Martin Green, a proven sports insider, has analyzed the match thoroughly and suggests leaning towards the Over 3.5 goals. Both teams have shown impressive offensive capabilities, averaging at least 2.50 goals per match in their domestic leagues. Madrid's attacking trio of Kylian Mbappe, Vinicius Junior, and Jude Bellingham has been particularly potent, scoring four goals in each of their last three home matches.

Conversely, Inter Milan has also demonstrated their offensive prowess, leading Serie A in goals last season and averaging 3.7 total goals in their early matches this season. However, their defense has weakened following the departure of goalkeeper Yann Sommer.

Green’s analysis points to an exciting, high-scoring affair, and he has locked in a series of confident picks for fans to consider. For those interested in betting insights, detailed predictions are available at SportsLine.