After a challenging Week 4, the predictions for NFL Week 6 show promise with a strong 10-4-1 record straight up and 9-6-1 against the spread. The season totals now stand at 48-30-1 and 34-43-2, respectively, as momentum builds.

Key Matchups:

• Seattle Seahawks (-3) at Denver Broncos
  Thursday, 8:15 p.m. on Amazon Prime
  The Seahawks face a tough road game after a loss to the 49ers. The Broncos' struggling offense positions Seattle for a narrow victory.
  Pick: Seahawks 23, Broncos 17

• Houston Texans at Jacksonville Jaguars (-3)
  Sunday, 9:30 a.m. on NFL Network
  The Jaguars, having adjusted to London, are set to edge the Texans in a close game.
  Pick: Jaguars 24, Texans 20

• Chicago Bears at Atlanta Falcons (+3)
  Sunday, 1 p.m. on Fox
  With the Bears reeling and the Falcons recovering from an overtime loss, Atlanta is favored to win.
  Pick: Falcons 27, Bears 21

• Baltimore Ravens (-4.5) at Cleveland Browns
  Sunday, 1 p.m. on Fox
  Whether or not Lamar Jackson returns, the Ravens' defense is expected to stifle the Browns.
  Pick: Ravens 24, Browns 13

• Tennessee Titans at Indianapolis Colts (-7)
  Sunday, 1 p.m. on Fox
  The Colts' improved defense should secure a win over the winless Titans.
  Pick: Colts 28, Titans 17

• New York Jets at New England Patriots (-7.5)
  Sunday, 1 p.m. on CBS
  The Patriots look to extend their winning streak against a Jets team that poses a challenge.
  Pick: Patriots 28, Jets 13

• New Orleans Saints at New York Giants (-1.5)
  Sunday, 1 p.m. on Fox
  The Giants are predicted to narrowly defeat the struggling Saints in a defensive battle.
  Pick: Giants 19, Saints 16

• Pittsburgh Steelers at Tampa Bay Buccaneers (+3)
  Sunday, 1 p.m. on CBS
  After recent victories, the Buccaneers are set to upset the Steelers.
  Pick: Bucs 26, Steelers 21

• Arizona Cardinals at Los Angeles Rams (-13.5)
  Sunday, 4:05 p.m. on Fox
  The Rams are anticipated to bounce back strongly against the Cardinals.
  Pick: Rams 35, Cardinals 20

• Los Angeles Chargers (+8.5) at Kansas City Chiefs
  Sunday, 4:25 p.m. on CBS
  The Chiefs, undefeated and coming off a bye, are favored to win against the desperate Chargers.
  Pick: Chiefs 28, Chargers 21

• Buffalo Bills (-6) at Las Vegas Raiders
  Sunday, 4:25 p.m. on CBS
  The Bills are expected to dominate the Raiders despite travel challenges.
  Pick: Bills 35, Raiders 21

• Dallas Cowboys at Green Bay Packers (-1.5)
  Sunday, 8:20 p.m. on NBC
  The Packers aim to continue their strong performance against a struggling Cowboys defense.
  Pick: Packers 31, Cowboys 27

• Washington Commanders at San Francisco 49ers (-7.5)
  Monday, 8:15 p.m. on ESPN
  The 49ers are predicted to maintain their winning streak against the Commanders.
  Pick: 49ers 30, Commanders 20