A solid start to the season has given confidence to NFL analyst Prisco, who achieved a 12-4 record straight up and 9-7 against the spread in Week 1. As Week 2 unfolds, he anticipates a mix of bounce-back performances from struggling teams and continued success from the strong ones.

Key Predictions for Week 2:

• Detroit Lions at Buffalo Bills
  Thursday, 8:15 p.m. on Amazon Prime
  The matchup promises high-scoring action. Prisco predicts a close contest, favoring the Bills to outlast the Lions.
  Pick: Bills 36, Lions 30

• Carolina Panthers at Atlanta Falcons
  The Falcons are expected to take advantage of the Panthers' defensive struggles.
  Pick: Falcons 21, Panthers 17

• Philadelphia Eagles at Tennessee Titans
  After a strong performance last week, the Eagles are poised to dominate the Titans.
  Pick: Eagles 30, Titans 13

• Cleveland Browns at Tampa Bay Buccaneers
  Expect a strong bounce-back from Baker Mayfield as the Buccaneers take control.
  Pick: Buccaneers 30, Browns 10

• Cincinnati Bengals at Houston Texans
  A marquee matchup; Prisco sees the Texans edging out the Bengals.
  Pick: Texans 28, Bengals 23

• New York Giants at Los Angeles Rams
  The Rams look to recover from their previous loss, with Matthew Stafford leading the charge.
  Pick: Rams to win decisively.

With the stakes high for many teams, Prisco's insights set the stage for an exciting weekend of NFL action.