A thrilling Week 10 college football matchup unfolds as the No. 12 Ohio State Buckeyes host the No. 23 Oregon Ducks at Ohio Stadium in Columbus, Ohio. Kickoff is set for 3:30 p.m. ET on CBS and Paramount+.

The Buckeyes, sporting a record of 6-2 and 4-1 in the Big Ten, recently suffered a setback, ending their five-game winning streak with a 30-18 loss to an unranked USC squad. In contrast, the Ducks (record: 5-3, 3-2 Big Ten) come off a notable 34-26 upset victory against No. 20 Northwestern in Week 9.

Both teams face challenges with their starting quarterbacks sidelined: Julian Sayin (Ohio State) is out due to an arm injury, while Dante Moore (Oregon) is recovering from a concussion. Despite this, the backup quarterbacks showcased impressive performances last week. Dylan Raiola threw for 336 yards and 3 touchdowns for Oregon, while Ohio State's Luke Fahey managed 260 yards, 1 touchdown, and no turnovers against USC.

The Buckeyes hold a narrow lead in their all-time series against the Ducks, 3-2, and are currently favored by 7.5 points. The over/under for total points is set at 45.5. SportsLine's advanced model predicts a high-scoring affair, forecasting the total to go Over 45.5 points based on trends from previous matchups, which have consistently seen scores exceed 60 combined points.

Key Predictions from SportsLine include:

• The model projects over 500 combined passing yards between the two quarterbacks.
• An impressive 5-1 record for the Over in Oregon's last six games as an underdog.

For those looking to make predictions, SportsLine suggests visiting their platform for detailed insights into the spread and money-line picks, as one side of the spread is expected to hit over 60% of the time.