As NFL Week 6 approaches, the excitement mounts with a slate of intriguing matchups. The focus shifts to the Carolina Panthers facing off against the Philadelphia Eagles on Sunday at 1 p.m. Jalen Hurts, the Eagles' starting quarterback, is sidelined due to a blood clot in his calf, leading to Tanner McKee making his debut in challenging circumstances. The Panthers come into this game with a significant rest advantage, having enjoyed a bye week, while the Eagles are recovering from an international game in London.

• Projected score: Panthers 26, Eagles 19
• Pick: Panthers -3

In another exciting matchup, the Pittsburgh Steelers travel to face the Tampa Bay Buccaneers, also on Sunday at 1 p.m. The Bucs aim to build on their recent upset victory over the Dallas Cowboys, while the Steelers might be caught looking ahead to their Week 7 game against the New Orleans Saints in Paris. The Buccaneers' defense, allowing the second-fewest rushing yards, could be pivotal in this contest.

• Projected score: Buccaneers 24, Steelers 23
• Pick: Buccaneers +2.5

The Tennessee Titans meet the Indianapolis Colts, with the Titans struggling this season but facing a Colts team that has not been efficient offensively.

• Projected score: Colts 24, Titans 20
• Pick: Titans +7

In the Arizona Cardinals vs. Los Angeles Rams matchup, the Rams look to rebound from an overtime loss, while the Cardinals aim to keep the game close despite not being favored.

• Projected score: Rams 30, Cardinals 20
• Pick: Cardinals +12.5

Finally, the New York Jets visit the New England Patriots, who have shown dominance at home and against losing teams.

• Projected score: Patriots 30, Jets 17
• Pick: Patriots -7.5

Other notable matchups include:

• Texans at Jaguars: Jaguars -2.5
• Ravens at Browns: Ravens -3
• Bears at Falcons: Bears -1.5
• Saints at Giants: Giants +1.5
• Bills at Raiders: Bills -5.5
• Chargers at Chiefs: Chiefs -7.5
• Cowboys at Packers: Cowboys +1.5

Week 6 promises to be filled with excitement and potential betting opportunities.