The 2026 NFL season has surprised fans with unexpected twists, including the Houston Texans starting 0-4 and the Cleveland Browns surprising everyone with a 3-1 record. This week, the Jacksonville Jaguars take on the Philadelphia Eagles in London, while other key matchups include the Chicago Bears visiting the Green Bay Packers and the San Francisco 49ers facing the Seattle Seahawks.

Key Matchups:

• Eagles vs. Jaguars (Sunday, 9:30 a.m. ET):
  The Eagles are struggling after blowing a 10-point lead against the Los Angeles Rams and facing injuries to star players like Saquon Barkley and DeVonta Smith. The Jaguars, boasting a strong run defense, aim to capitalize on the Eagles' misfortunes. Jordan Dajani predicts the Jaguars will cover the spread.

• Bears at Packers (Sunday, 1 p.m. ET):
  A fierce rivalry with the Packers favored by 3 points. Expect a standout performance from Jordan Love as the Packers look to upset the Bears.

• Texans at Titans (Sunday, 1 p.m. ET):
  Both teams are 0-4, but C.J. Stroud is expected to lead the Texans to their first victory, despite tough competition.

Additional Insights:

• The Minnesota Vikings remain undefeated at 4-0 and face a struggling New Orleans Saints team.
• Lamar Jackson's injury could impact the Baltimore Ravens against the Atlanta Falcons, who are finding their rhythm with Michael Penix at quarterback.

As betting picks are analyzed, experts from CBS Sports and SportsLine provide insights on which teams can be trusted this week. With predictions running high, the excitement for Week 5 promises thrilling football action.