As October arrives, Week 4 of the NFL season promises exciting matchups as teams aim to distinguish themselves from the pack. This week marks the first of three London Games and features a heated division rivalry on Monday Night Football.

Key Matchups:

• Indianapolis Colts vs. Washington Commanders
  Time: Sunday, 9:30 a.m. ET
  Open: Commanders -1.5, O/U 48.5
  Both teams seek their second win after showing improvement last week. Expert Pete Prisco predicts a close finish, favoring the Colts 31-30.

• New England Patriots vs. Buffalo Bills
  Time: Sunday, 1 p.m. ET
  Open: Bills -3, O/U 49.5
  The Patriots look to rebound from a dismal 35-6 loss, while the Bills aim to maintain their unbeaten streak.

• New York Jets vs. Chicago Bears
  Time: Sunday, 1 p.m. ET
  Open: Bears -8.5, O/U 45.5
  With an impressive performance last week, the Bears are expected to secure a home victory.

• Jacksonville Jaguars vs. Cincinnati Bengals
  Time: Sunday, 1 p.m. ET
  Open: Bengals -2.5, O/U 51.5
  The Bengals, aiming to break their winning streak against Lawrence, could face challenges from the Jaguars.

• Denver Broncos vs. San Francisco 49ers
  Time: Sunday, 4:25 p.m. ET
  Open: 49ers -2.5, O/U 46.5
  The 49ers are primed to remain undefeated, according to expert Jared Dubin.

Additional Insights:

• Dallas Cowboys are predicted to cover against the Houston Texans, who struggle offensively.
• The Minnesota Vikings face a depleted Miami Dolphins team, with experts favoring a Vikings win.
• Kansas City Chiefs are favored against the Las Vegas Raiders in a crucial AFC West clash.

As the action unfolds, fans can expect thrilling performances and potential upsets across the league.