With Week 1 of the NFL season just 10 days away, making survivor pool picks becomes a daunting challenge due to the absence of in-season data. Among the notable matchups, key games include 49ers vs. Rams (-3.5), Packers vs. Vikings (-1.5), Commanders vs. Eagles (-4.5), and Cowboys vs. Giants (+2.5). The Minnesota Vikings, initially 1.5-point underdogs, are now favored following the announcement of Kyler Murray as the starting quarterback.

The matchup between the Cardinals and Chargers (-10.5) stands out, as Arizona grapples with a nine-game losing streak, the longest in the league, and no clear solution at quarterback. This raises the question: is this the ideal game for survivor pool picks, or should players hold off on selecting the Chargers?

The SportsLine Projection Model, which has proven successful with over $7,000 in returns for $100 players on top-rated picks, is now focusing on Week 1. It has established a strong performance record, entering the 2026 season with a 53-37 run on its picks since 2024.

For Week 1, the model advises against picking the Dallas Cowboys (-2.5), despite being -148 favorites against the New York Giants, who finished last season with a 4-13 record and have a new coaching staff led by John Harbaugh. Dak Prescott, entering his 11th season, had an impressive 2025, throwing for 4,552 yards and 30 touchdowns. However, the Cowboys have struggled in recent Week 1 games, going 2-4 in their last six outings. The model indicates the Giants have a 49% chance of winning in simulations, making the Cowboys a risky choice.

Instead, the model confidently backs a different team, projected to win outright in over 80% of simulations. For detailed insights on the best pick, players should check the recommendations at SportsLine.