Los Angeles Rams 24–20 Philadelphia Eagles
The Los Angeles Rams staged a dramatic comeback against the Philadelphia Eagles, overcoming a 10-point deficit late in the game. Kyren Williams scored two crucial touchdowns in the final four minutes, leading the Rams to victory after Matthew Stafford orchestrated impressive touchdown drives of 98 and 79 yards. The Eagles' decision to go for it on fourth down instead of kicking a field goal proved costly, allowing the Rams to seize momentum. Both teams now sit at 2-2 for the season.

Kansas City Chiefs 30–27 Las Vegas Raiders
In a nail-biting finish, Patrick Mahomes led the Kansas City Chiefs to victory over the Las Vegas Raiders. Mahomes passed for 225 yards and two touchdowns, with Kenneth Walker III rushing for 177 yards and scoring the go-ahead touchdown. However, the game was marred by a serious injury to Tyquan Thornton, who was carted off after making a crucial catch. The Chiefs improved to 4-0, while the Raiders fell to 3-1.

New England Patriots 29–26 Buffalo Bills
Drake Maye threw for 269 yards and three touchdowns, including a pivotal pass to Efton Chism III, leading the New England Patriots to their second win of the season. The victory handed the Buffalo Bills their first loss at home.

Denver Broncos 14–24 San Francisco 49ers
Brock Purdy and Christian McCaffrey propelled the undefeated San Francisco 49ers to victory against the Denver Broncos, who fell to 2-2.

Dallas Cowboys 34–30 Houston Texans
CeeDee Lamb's career-high 17 catches helped the Dallas Cowboys secure a thrilling win over the Houston Texans, who remain winless.

Tennessee Titans 18–24 Baltimore Ravens
Despite Lamar Jackson leaving early with an ankle injury, the Baltimore Ravens held on for a win against the Tennessee Titans, who dropped to 0-4.

Seattle Seahawks 30–23 Los Angeles Chargers
The Seattle Seahawks handed the Los Angeles Chargers their fourth consecutive loss.

New York Giants 36–24 Arizona Cardinals
Jameis Winston led the New York Giants to victory, marking their third win of the season.

Chicago Bears 23–12 New York Jets
Kyle Monangai's two rushing touchdowns helped the Chicago Bears secure a win over the New York Jets.

Minnesota Vikings 15–10 Miami Dolphins
TJ Hockenson shined for the Minnesota Vikings, who improved to 4-0.

Jacksonville Jaguars 22–17 Cincinnati Bengals
Trevor Lawrence led the Jacksonville Jaguars to a narrow victory, forcing critical turnovers against the Cincinnati Bengals.

Green Bay Packers 17–14 Tampa Bay Buccaneers
Jordan Love threw two touchdowns, guiding the Green Bay Packers to victory over the Tampa Bay Buccaneers.

Indianapolis Colts 30–13 Washington Commanders
Jonathan Taylor was instrumental in the Indianapolis Colts' win over the Washington Commanders, who faced yet another quarterback injury.