The Week 4 NFL schedule brings exciting matchups, including Patriots vs. Bills, Cowboys vs. Texans, and Broncos vs. 49ers, as part of a full 16-game slate. With several weeks of data to analyze, SportsLine's experts have made confident picks for this week’s games.

Key Matchups and Predictions:

• Colts vs. Commanders (9:30 a.m. ET)

  • Pick: Colts (-3)
  • R.J. White highlights the Commanders’ struggles despite a surprise win against the Seahawks, suggesting the Colts will dominate.

• Patriots vs. Bills (1 p.m. ET)

  • Pick: Bills (-6.5)
  • White expresses concerns over the Patriots' offense, predicting a strong performance from Josh Allen and the Bills.

• Rams vs. Eagles (1 p.m. ET)

  • Pick: Kyren Williams, Rams, Over 55.5 rushing yards
  • Doug emphasizes Williams’ consistent performance and the Eagles' vulnerability against the run.

• Titans vs. Ravens (1 p.m. ET)

  • Pick: Wan'Dale Robinson, Titans, Over 3.5 receptions
  • Doug notes Robinson's ability to thrive in a passing-heavy game script against the Ravens.

• Cowboys vs. Texans (1 p.m. ET)

  • Pick: Texans (-2.5)
  • White believes the Texans can capitalize on the Cowboys' recent struggles and injury issues.

• Dolphins vs. Vikings (4:05 p.m. ET)

  • Pick: Malik Willis, Dolphins, Over 26.5 total rushing yards
  • Doug indicates that the Dolphins might lean on Willis’ legs more after losing De'Von Achane.

• Broncos vs. 49ers (4:25 p.m. ET)

  • Pick: Broncos (+3)
  • Hartstein anticipates a tough matchup for the 49ers against a resilient Broncos defense.

• Lions vs. Panthers (Sunday Night Football, 8:20 p.m. ET)

  • Pick: Panthers (+3.5)
  • Hartstein suggests that despite injuries, the Panthers could keep it close against the Lions.

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