As Chad Ryland's 43-yard field goal sailed through the uprights as time expired, the Arizona Cardinals clinched an 18-16 victory over the Los Angeles Rams, marking the largest upset of the season. Entering the game as 13.5-point underdogs, this win tied for the biggest upset in the last five years and marked the largest upset loss of Matthew Stafford's career.

The Cardinals, who did not score a touchdown, managed to lead 15-12 with under three minutes remaining. Matthew Stafford orchestrated a quick touchdown drive, highlighted by significant completions to Puka Nacua, culminating in a 5-yard touchdown pass to Colby Parkinson with 47 seconds left. However, the Rams’ defense faltered in the final moments, allowing Jacoby Brissett to connect with Jalen Brooks for a critical 21-yard gain, followed by a 15-yard penalty that set up Ryland's game-winner.

Arizona's first win since the season opener showcased a strong defensive performance, recovering from a previous 45-point concession, while their offense accumulated 338 yards across six scoring drives, all field goals. In contrast, the Rams, now 2-4, have failed to live up to their Super Bowl aspirations, mirroring the Cardinals' record.

The Rams' offense struggled significantly, with Stafford completing only 25 of 33 passes for 222 yards and two touchdowns, but averaging a mere 4.6 yards per attempt. Key offensive mistakes, including a fumble by Tyler Higbee and critical penalties, hindered their performance.

Defensively, the Rams recorded no sacks against an underwhelming offense, while their special teams issues continued, highlighted by a significant kickoff return allowed and the injury of kicker Blake Grupe. Overall, the Rams are grappling with major deficiencies across all facets of the game, leaving Sean McVay and his coaching staff searching for solutions as their nightmare season deepens.