The Jacksonville Jaguars (5-2) aim for their fifth victory in six games as they face the Baltimore Ravens (4-4) on 'Thursday Night Football.' Jacksonville comes off a dominant 42-7 win against the Indianapolis Colts, while Baltimore suffered a 36-10 loss at Buffalo.

The Ravens face significant challenges at quarterback, with Lamar Jackson on injured reserve due to a thumb injury and Tyler Huntley ruled out with a toe issue. This leaves undrafted rookie Joe Fagnano, who is nursing an ankle injury, as the potential starter if he can play.

Kickoff is scheduled for 8:15 p.m. ET at M&T Bank Stadium in Baltimore. Historically, Jacksonville leads the series 13-11, but Baltimore has won three of the last five matchups. Current odds favor Jacksonville by 8.5 points, with an over/under of 42.5 points.

Before placing any bets, consider insights from SportsLine’s proven model, which has successfully simulated every NFL game 10,000 times and boasts a profit of over $5,000 for $100 players on top-rated NFL picks since its inception. The model's record stands at 60-51 on top-rated picks since 2024.

Key betting lines for the game include:

• Spread: Jaguars -9.5
• Over/Under: 42.5 points
• Money Line: Jaguars -476, Ravens +385

Notably, the model predicts the game will go Over 42.5 points, which has occurred in three of their last four meetings. Quarterback Trevor Lawrence leads Jacksonville with 1,690 passing yards and 17 touchdowns this season, while Derrick Henry spearheads the Ravens' offense with 632 rushing yards and eight touchdowns.

For those looking for betting strategies, the model suggests one side of the spread offers better value. Check SportsLine for detailed predictions.