The Jacksonville Jaguars have suffered a significant setback as defensive tackle DaVon Hamilton appears to have sustained a season-ending injury. Hamilton tore his quad during the team's 42-7 victory over the Indianapolis Colts. This injury is a major blow for a Jaguars squad that holds Super Bowl aspirations. Hamilton, who is expected to miss the remainder of the season, will undergo further testing to assess the full extent of the injury.

At 29 years old, Hamilton has been a key player for the 5-2 Jaguars, who currently lead the NFL in various defensive categories, including:

• Yards per rush allowed: 3.4
• Rushing yards per game allowed: 77.4
• Defensive rushing success rate: 61.9%

His performance has been instrumental, as no opponent has managed to rush for over 56 yards against the Jaguars this year. Hamilton’s contributions extend beyond traditional stats; he even served as an emergency long snapper in a previous game. His run defense grades rank him ninth in Pro Football Focus for interior defensive linemen.

With Hamilton sidelined, the Jaguars are actively seeking a replacement. They already had plans to bolster the interior line, with players like Arik Armstead, Ruke Orhorhoro, Matt Dickerson, and rookie Albert Regis in the mix. However, none match Hamilton’s prowess against the run.

Here are five potential trade targets for Jacksonville:

• Otito Ogbonnia (Cowboys): A solid run defender, Ogbonnia ranks eighth in PFF's run defense grades and could be a valuable addition.
• Grover Stewart (Colts): An in-division trade, Stewart has a history of production and could be available as the Colts look to rebuild.
• Jowon Briggs (Jets): At just 25, Briggs offers versatility and could benefit from a fresh start if the Jets decide to trade him.
• Roy Lopez or Andrew Billings (Cardinals): Both players could provide necessary depth and skill to the Jaguars' defensive line.

With the trade deadline approaching, the Jaguars aim to fill the void left by Hamilton and maintain their defensive strength.