Kyle Shanahan has voiced concerns regarding the San Francisco 49ers' challenging schedule this season, which places them among five teams facing an unprecedented scheduling disadvantage. This year, teams playing international games must follow up with matches against opponents coming off a bye week—a scenario that has historically proven unfavorable.

In Week 11, the 49ers travel internationally, only to face the Seattle Seahawks in Week 12, a team that will be well-rested after a bye. This unique setup puts the 49ers at a distinct disadvantage, as they deal with international travel while the Seahawks prepare at home.

The other teams affected include:

• Philadelphia Eagles: Playing in London against the Jacksonville Jaguars in Week 5, followed by a game against the Carolina Panthers coming off a bye.
• Cincinnati Bengals: Competing in Spain against the Atlanta Falcons in Week 9, then hosting the Pittsburgh Steelers who have a bye week prior.
• Detroit Lions: Facing the New England Patriots in Germany in Week 10, then playing the Tampa Bay Buccaneers who are also coming off a bye.
• Minnesota Vikings: Playing in Mexico City against the 49ers, then facing the Falcons, who will be rested after a bye.

Historically, teams in this position have struggled. In four prior instances where a team coming off an international game faced one coming off a bye, they have lost all four matchups. The average points scored by these teams stands at a mere 15.25, with significant scoring deficits.

With the NFL's scheduling policies evolving, teams are now less likely to receive a bye after international games. If the Eagles, Bengals, and Lions struggle following their international games, the league may need to reconsider this scheduling approach to ensure competitive fairness.