In a tough turn of events for the San Francisco 49ers, wide receiver Deebo Samuel sustained a hamstring injury during the second half of their Week 5 victory against the Seattle Seahawks. The injury occurred late in the third quarter while the 49ers were trailing 23-21. Samuel remained on the ground after fumbling the ball, which led to a Seattle field goal.

Following further evaluations, 49ers coach Kyle Shanahan confirmed that Samuel will be out for "at least a couple of weeks." The 49ers are set to face Washington on "Monday Night Football" next week, followed by a matchup against the Atlanta Falcons in Week 7 and a bye in Week 8.

In Samuel's absence, the 49ers will rely on other key players:

• Brandin Cooks, who recently joined the team, caught a touchdown pass from Brock Purdy.
• Mike Evans had a standout performance with seven receptions for 113 yards and a touchdown, despite dealing with two fractured ribs.

Samuel, who is 30 years old, has made a significant impact since rejoining the 49ers after spending the 2025 season with the Washington Commanders. He is currently tied for second on the team with three touchdown catches and ranks second in receptions, contributing four runs that resulted in first downs.

Despite the injury challenges, the 49ers remain one of only three undefeated teams in the league, holding a two-game lead in the NFC West division.