The Philadelphia Eagles (2-5) seek to end a five-game losing streak when they face the Washington Commanders (1-4-1) in a crucial NFC East matchup on Sunday Night Football. After suffering a 38-21 defeat to the Dallas Cowboys on Monday Night Football, the Eagles aim to rebound against a struggling Commanders team that recently lost 23-17 to the San Francisco 49ers on October 19.

Both teams are grappling with notable injuries. The Eagles will be without quarterback Jalen Hurts (blood clots) and receiver DeVonta Smith (hamstring), while the Commanders will miss receiver Terry McLaurin (knee) for the remainder of the season.

Kickoff is scheduled for 8:20 p.m. ET at Northwest Stadium in Landover, Md. The latest odds show Washington favored by 6 points, with an over/under set at 40.5 total points.

Before placing any bets on the Eagles vs. Commanders, consider insights from SportsLine's proven model, which has simulated the matchup 10,000 times. The model boasts a record of over $5,000 in profit for $100 players on top-rated NFL picks since its inception and has a 58-51 run on such picks since 2024.

Key betting lines include:

• Spread: Commanders -6
• Over/Under: 40.5 points
• Money Line: Commanders -265, Eagles +220

The model predicts the game will go Over 40.5 points, as this outcome has occurred in eight of the last ten matchups between the two teams. Philadelphia's running back Saquon Barkley, despite a back issue, has been a key player, accumulating 244 yards and one touchdown this season. The Commanders' offense is spearheaded by quarterback Jayden Daniels, who has thrown for 759 yards and five touchdowns without any interceptions in four starts.

With the model projecting 43 combined points, it indicates that the Over hits 54% of the time. For detailed predictions and insights on which side of the spread to back, visit SportsLine.