The Week 10 college football landscape presents a thrilling array of matchups, particularly in the SEC with Alabama facing LSU (-5.5), Georgia against Ole Miss (+3.5), and Texas meeting Missouri (+2.5). A highlight includes a top-5 clash as the No. 1 Miami Hurricanes visit No. 11 Notre Dame, with the Fighting Irish favored by 7.5 points, aiming to avenge last year's loss while the Canes miss star wideout Malachi Toney due to injury.

Out west, the storied rivalry known as the Holy War pits BYU against Utah, where the third-ranked Utes are favored by 5.5 points at home. SportsLine's computer model, which simulates every FBS game 10,000 times, recommends strategic picks for these matchups, entering Week 10 with an 80-77 record on top-rated college football bets this season.

Top College Football Predictions for Week 10

• Ohio State (-7.5, 46.5) is projected to cover against Oregon in their 3:30 p.m. ET kickoff. Following a loss at USC, freshman QB Luke Fahey returns home against a Ducks defense that has allowed numerous passing touchdowns. The Buckeyes have a strong home cover rate, winning by double digits over 60% of the time.

• Oklahoma (+6.5, 44.5) is also favored to cover against Florida. The Gators have struggled, losing three of four games by significant margins. With QB John Mateer averaging impressive stats and Florida leading the SEC in penalty yards, the model expects Oklahoma to perform well.

The model has also projected three upsets among ranked teams, emphasizing its reliability for making confident picks. For full insights and predictions for every game, fans can turn to SportsLine, where expert analysis awaits.