In the final game of Week 1, the Kansas City Chiefs host division rival Denver Broncos on Monday Night Football. Kansas City enters this matchup after a disappointing 6-11 season, marking their first playoff miss since 2014. Formerly dominant, the Chiefs aim to reclaim their division title, especially with Patrick Mahomes returning from a torn ACL.

Conversely, the Broncos enjoyed a stellar 14-3 record in 2025, securing the No. 1 seed in the AFC but falling short in the AFC title game without starting quarterback Bo Nix, who is now back from a broken ankle. This game promises to be a pivotal moment for both teams as they battle for supremacy in the AFC West.

Key Details

• Date: Monday, Sept. 14
• Time: 8:15 p.m. ET
• Location: Arrowhead Stadium, Kansas City
• TV: ESPN/ABC
• Odds: Chiefs -2.5, O/U 43.5 via DraftKings Sportsbook

Player Highlights

• Patrick Mahomes struggled last season with a career-low completion rate of 62.7% and only 22 touchdown passes. He aims to improve as a passer and reduce his rushing attempts post-injury.
• Bo Nix has thrown for over 3,700 yards and 25 touchdowns in both of his first two seasons. His return is critical for the Broncos as he looks to enhance their offensive capabilities.

Roster Changes

• The Chiefs signed Kenneth Walker III to strengthen their running game, while Jaylen Waddle joins the Broncos, expected to be a key target for Nix.
• Josh Simmons, the Chiefs' left tackle, is out, forcing undrafted rookie Khalil Benson to protect Mahomes' blind side against a fierce Denver pass rush.
• The Broncos will miss Jonathan Cooper, placed on the exempt list due to legal issues.

Prediction

While Mahomes' return is exciting, the Chiefs may struggle against the Broncos' formidable defense. Expect a heavy reliance on the running game led by Walker, but Nix's effectiveness could secure a win for Denver in this thrilling Week 1 encounter.