As the Arizona Cardinals gear up for the 2026 season, the quarterback position remains a focal point of speculation. Jacoby Brissett emerges as the frontrunner to start in Week 1 against the Los Angeles Chargers on September 13. With odds at -295, Brissett's role appears secure, unless contract demands disrupt his participation.

The Cardinals, coming off a dismal campaign where they recorded a franchise-worst 14 losses, are in a significant transition. After firing former coach Jonathan Gannon, the team has brought in Mike LaFleur, marking the sixth consecutive head coach without prior permanent NFL experience. Arizona's win total projection sits at an Over/Under of 4.5, tied for the lowest in the league, and they are the favorites at +250 to finish with the fewest wins.

Brissett, who had a challenging season last year with a 1-11 record as a starter, showcased potential despite team struggles. He led the league in completions and attempts during a nine-game losing streak, throwing for 3,366 yards, 23 touchdowns, and 8 interceptions, achieving a rating of 94.1—his second-best career mark.

However, contract negotiations complicate matters. Brissett seeks a raise from his current salary of $4.88 million, which is low compared to other starting quarterbacks. While he reported to the recent mini-camp to avoid fines, his desire for more guaranteed money remains a significant issue.

In the quarterback race, Gardner Minshew and rookie Carson Beck are listed as potential starters at +370 and +700, respectively, but their chances hinge on Brissett's commitment to the team. As the Cardinals prepare for the upcoming season, all eyes are on Brissett's ability to navigate both the field and the complexities of his contract.