Josh Allen faces a daunting challenge as the Buffalo Bills visit the Houston Texans for their 2026 NFL season opener on Sunday. Allen has struggled in Houston, holding an 0-4 record at Reliant Stadium, including a tough 23-19 loss last season where he was sacked eight times. With new head coach Joe Brady and star receiver DJ Moore, the Bills aim to overcome their historical struggles.

Kickoff is scheduled for 1 p.m. ET and the game will be broadcast on CBS and Paramount+. The latest odds favor the Bills by 1 point, with an over/under set at 44.5 points. The Bills' money line stands at -117, while the Texans are at -102.

The SportsLine Projection Model, known for its accuracy, has analyzed the matchup extensively, simulating the game 10,000 times. The model has consistently delivered strong returns, boasting a 53-37 record on top-rated picks since 2024, yielding over $7,000 for players betting $100.

Key predictions include:

• James Cook of the Bills projected for 83 rushing yards.
• C.J. Stroud aiming for a comeback season, with Nico Collins expected to grab 69 receiving yards.

The model predicts a combined total of 46 points, suggesting a high-scoring affair despite Allen's previous struggles in Houston. Furthermore, it highlights one side of the spread hitting over 60% of the time.

For those betting on this matchup, checking the model's insights could prove beneficial as the Bills and Texans clash in this intriguing Week 1 opener.