The Buffalo Bills make their regular-season debut at Highmark Stadium as they face the Detroit Lions in an exciting matchup for Week 2 of the NFL season. The game kicks off at 8:15 p.m. ET on Thursday night, setting the stage for a thrilling encounter.

Both teams enter the game with early-season momentum: the Bills secured a 36-31 victory over the Houston Texans in Week 1, while the Lions narrowly edged out the New Orleans Saints with a 31-30 win in overtime.

Key Matchup Details:

• Bills Record: 1-0 (2nd in AFC East, finished 12-5 last season)
• Lions Record: 1-0 (4th in NFC North, finished 9-8 last season)
• Point Spread: Buffalo -4.5
• Over/Under: 53.5 points
• Money Line: Buffalo -224, Detroit +185

The SportsLine projection model, which simulates every NFL game 10,000 times, has been profitable, boasting over $7,000 in returns for $100 players on top-rated NFL picks. The model has been on a 53-39 run on these picks since 2024.

Player Highlights:

• Jahmyr Gibbs (Lions RB): 29 carries for 156 yards and 2 touchdowns, plus 5 receptions for 30 yards.
• Jared Goff (Lions QB): Completed 26 of 39 passes for 206 yards and 2 touchdowns.
• Josh Allen (Bills QB): Completed 20 of 29 passes for 334 yards and 2 touchdowns, rushing for 23 yards and 2 scores.
• Dalton Kincaid (Bills TE): Caught 5 of 6 passes for 130 yards.

The model predicts a total of 58 combined points, indicating strong value on the Over, which has hit in 7 of the last 10 games for the Lions and 6 of the last 10 for the Bills.

For those looking to make informed betting decisions, the model also highlights a side of the spread that is favored in over 50% of simulations. Check out SportsLine for expert picks and insights.