The Buffalo Bills and coach Joe Brady are set to make their Highmark Stadium regular-season debut against the Detroit Lions on Thursday Night Football as the Week 2 NFL schedule kicks off. The Bills began the season with a thrilling 36-31 victory over the Houston Texans, while the Lions narrowly defeated the New Orleans Saints 31-30 in overtime.

Match Details:

• Date: Thursday, Week 2
• Kickoff: 8:15 p.m. ET
• Location: Highmark Stadium, Buffalo

The latest odds indicate the Bills as 5.5-point favorites, up from an opening line of Buffalo -3. The over/under for total points is set at 54.5. The SportsLine projection model, which has proven profitable with over $7,000 in returns for $100 players since its inception, has analyzed this matchup.

Key Player Performances:

• Jahmyr Gibbs (Lions): 29 carries, 156 yards, 2 TDs; 5 receptions, 30 yards.
• Jared Goff (Lions): 26 completions on 39 attempts for 206 yards and 2 TDs.
• Josh Allen (Bills): 20 completions on 29 attempts for 334 yards and 2 TDs; 6 rushes for 23 yards and 2 TDs.
• Dalton Kincaid (Bills): 5 receptions for 130 yards.

The model predicts a total of 59 combined points, suggesting significant offensive output from both teams. Historically, the Over has hit in 7 of the last 10 games for the Lions and 6 of the last 10 for the Bills, making this matchup one to watch.

For those looking to make informed betting decisions, the model also highlights a side of the spread that is predicted to hit in over 50% of simulations. Further insights and picks can be found at SportsLine.