The Buffalo Bills are set to make their Highmark Stadium regular-season debut as they go head-to-head with the Detroit Lions in a highly anticipated matchup on Thursday Night Football. This game kicks off the Week 2 NFL schedule at 8:15 p.m. ET.

Both teams enter this game with strong performances from Week 1. The Bills secured a thrilling 36-31 victory over the Houston Texans, while the Lions edged out the New Orleans Saints in a nail-biting 31-30 overtime win.

Key details of the matchup include:

• Kickoff: 8:15 p.m. ET
• Current Odds:
  • Spread: Buffalo -5.5 (up from -3)
  • Over/Under: 54.5 points
  • Money Line: Buffalo -249, Detroit +205

The Lions will be missing two starting offensive linemen, including first-round pick Blake Miller from the 2026 draft. The model predicts a high-scoring game, projecting over 59 combined points based on the offensive capabilities displayed in Week 1.

Standout players to watch:

• Jahmyr Gibbs (Lions): 29 carries for 156 yards and 2 touchdowns
• Jared Goff (Lions): Completed 26 of 39 passes for 206 yards and 2 touchdowns
• Josh Allen (Bills): Completed 20 of 29 passes for 334 yards and 2 touchdowns, with 2 rushing touchdowns
• Dalton Kincaid (Bills): 5 receptions for 130 yards

The model, which simulates every NFL game 10,000 times, has a proven track record, returning over $7,000 for $100 players on top-rated NFL picks. As the Bills and Lions prepare to clash, fans and bettors alike are eager to see how this exciting matchup unfolds.