The San Francisco 49ers bring their perfect record to Seattle this Sunday, set to clash with the Seattle Seahawks in a crucial NFC West matchup. Currently at 4-0, quarterback Brock Purdy has led the 49ers with impressive stats, contributing to a defense that ranks seventh in yards allowed.

On the other side, the Seahawks, boasting a 3-1 record, benefit from the support of the 12th Man and feature the league's top-ranked defense in yards allowed. Last season, this unit limited the 49ers to just nine points during a sweep, showcasing their strength on the way to a Super Bowl championship.

This game kicks off at 4:25 p.m. ET from Lumen Field. The latest odds see the Seahawks as 3-point favorites, with an over/under set at 45.5 points. Before finalizing any predictions, it's essential to consider insights from the SportsLine projection model, which has successfully simulated this matchup 10,000 times, accumulating over $7,000 in profit for $100 players on top-rated NFL picks.

Key betting lines for the game include:

• Spread: Seahawks -3
• Over/Under: 45.5 points
• Money Line: Seahawks -162, 49ers +136

The model projects that both teams will score effectively, predicting an over of 45.5 points. The Seahawks have consistently scored over 30 points in their last three games, while the 49ers have tallied 35 and 36 points in two of their last three outings. Notably, Nick Bosa will miss this game, potentially tilting the advantage towards Seattle’s offense.

Prominent players such as Jaxon Smith-Njigba have made significant impacts, already racking up 481 receiving yards and six touchdowns this season. Meanwhile, the 49ers' offense features a balanced attack with George Kittle, Mike Evans, and Deebo Samuel Jr., each contributing over 185 receiving yards.

With the model favoring one side in over 50% of simulations, bettors are encouraged to check SportsLine for the most informed picks.