A new NFL season ignites excitement and fresh expectations, particularly for the Los Angeles Rams, who have significantly strengthened their defense. The Rams welcomed Myles Garrett, a nine-time Pro Bowler and the 2025 NFL Defensive Player of the Year, alongside the return of Aaron Donald. This offseason's upgrades position them as serious contenders for a Super Bowl run.

In the opening game on September 10 in Melbourne, Australia, the Rams are 3.5-point favorites against the San Francisco 49ers. Other notable matchups include:

• New England Patriots vs. Seattle Seahawks (-3.5, 44.5)
• Buffalo Bills vs. Houston Texans (+1.5, 44.5)
• Dallas Cowboys vs. New York Giants (+3, 48)

Before placing any bets, it's crucial to consult the exact score predictions from SportsLine’s model, which has successfully simulated every NFL game 10,000 times. This model has shown impressive results, yielding over $7,000 in profits for $100 players since its inception and boasts a 53-37 record on top-rated picks since 2024.

Among the model's top Week 1 picks, it backs the Philadelphia Eagles (-5.5) to triumph over the Washington Commanders with a projected score of 27-18. The Eagles have dominated this rivalry, winning seven of the last ten encounters, while the Commanders have struggled, losing eight of their last ten games.

Key player projections include:

• Jalen Hurts (Eagles): 213 passing yards, 1.79 touchdowns
• Saquon Barkley (Eagles): Nearly 100 rushing yards, 1 touchdown
• DeVonta Smith (Eagles): Five receptions for nearly 75 yards
• Jayden Daniels (Commanders): Over 175 passing yards, 1 touchdown
• Jacory Croskey-Merritt (Commanders): Nearly 50 rushing yards

The model has also locked in exact score predictions for significant matchups, including an underdog expected to pull off a surprise upset. For detailed predictions, visit SportsLine.