A new NFL season is on the horizon, bringing fresh expectations for teams like the Los Angeles Rams. With significant defensive upgrades, including Myles Garrett's arrival and the return of Aaron Donald, the Rams aim for a Super Bowl run. Garrett, a former Cleveland Browns star, was named 2025 NFL Defensive Player of the Year after setting a single-season sack record with 23.

As the Rams prepare to face the San Francisco 49ers in Melbourne, Australia, on September 10, they enter the matchup as 3.5-point favorites. Other notable Week 1 spreads include:

• New England Patriots vs. Seattle Seahawks (-3.5, 44.5)
• Buffalo Bills vs. Houston Texans (+1.5, 44.5)
• Dallas Cowboys vs. New York Giants (+2.5, 48.5)

Before placing bets, it's crucial to check the exact score predictions from SportsLine's proven model, which has simulated every NFL game 10,000 times. This model has shown impressive results, earning over $7,000 for $100 players since its inception and maintaining a 53-37 record on top-rated picks since 2024.

In analyzing the Philadelphia Eagles vs. Washington Commanders game, the model predicts the Eagles will win 27-18, supported by strong recent performance against the Commanders, having won seven of their last ten meetings. Key player projections include Jalen Hurts with 213 yards and 1.79 touchdowns, and Saquon Barkley rushing for nearly 100 yards and a touchdown.

Additionally, the model has locked in exact score predictions for other key matchups, including Patriots vs. Seahawks, Bills vs. Texans, and Cowboys vs. Giants, and anticipates an underdog upset. For the most accurate predictions, fans should visit SportsLine.