The Week 1 NFL schedule launches with the Seahawks facing the Patriots on Wednesday, marking the start of an exciting week filled with games across the days. NFL bettors have a variety of matchups to analyze, with the Chargers currently favored at -10 against the Cardinals, while three other games have a close line of -1.5.

To assist bettors, SportsLine expert Eric Cohen provides detailed score predictions for all 16 games. With a successful record of 188-96-1 (66%) from the previous season, Cohen’s insights are invaluable for forming spread picks, over/under plays, and more.

Among his top recommendations, Cohen highlights the Texans (+1.5, 44.5) to prevail over the Bills. A win for Houston offers a -105 return on the money line. Cohen emphasizes that Josh Allen has struggled in road games, accumulating 10 turnovers in three starts, and notes that the Texans' defense, which performed strongly against him last year, will be a significant factor.

Key points include:

• Houston has won four of the last five matchups against Buffalo, all by a single possession.
• The Texans are regarded as having the best defense in the NFL.
• C.J. Stroud, the Texans' QB, will aim to improve from a challenging previous season.

Cohen forecasts a close game, predicting a score of Texans 23, Bills 20. He also suggests that a road team may achieve a double-digit victory, making alternate lines appealing for bettors. For more predictions, visit SportsLine.