Week 1 of the 2026 NFL preseason kicks off with a thrilling slate of three games on Friday at 7 p.m. ET. This opening night features all AFC teams battling against NFC opponents, including notable matchups like Broncos vs. Falcons (+5.5) and Dolphins vs. Commanders (+2.5). However, the highlight is the Jets vs. Buccaneers, where the New York Jets are favored by 6 points.

The absence of Baker Mayfield for Tampa Bay significantly impacts the matchup, while the Jets plan to field their starters, which increases their chances of a strong performance. Notably, the Denver Broncos boast a flawless 6-0 preseason record over the last two years, contrasting sharply with the Atlanta Falcons, who are winless at 0-6 during the same period.

Larry Hartstein, a seasoned analyst from SportsLine, has been tracking the NFL preseason closely and has locked in his best bets for Friday's games. With a solid 50-37-1 record (57.5%) from last season, his insights are invaluable for bettors.

One of Hartstein's top recommendations is to back the Jets (-6) at home. He emphasizes that the Jets' coach Aaron Glenn is known for utilizing starters in preseason games, as evidenced by last year's 30-10 victory against the Packers in their opener. Hartstein noted that rookie quarterback Cade Klubnik has been impressive in training camp, adding depth to the Jets' roster.

In addition to the Jets, Hartstein has identified two more best bets for Friday, including an intriguing underdog pick. For those looking to make informed bets this preseason, Hartstein's expertise offers a reliable guide to navigating the odds and spreads.

Overall, the Week 1 NFL preseason promises excitement and opportunities for savvy bettors, with updated lines available for each matchup.