The New England Patriots face off against the Seattle Seahawks in the 2026 NFL Kickoff Game, marking a rematch of last year's Super Bowl. Scheduled for Wednesday night at 8:20 p.m. ET at Lumen Field in Seattle, the game kicks off the regular season.

Seattle, the reigning Super Bowl champions, concluded the 2025 season with a 14-3 record, dominating the NFC West. They boasted a strong 6-2 record at home. In contrast, New England also finished with a 14-3 record, securing the AFC East title and reaching the Super Bowl for the 12th time in franchise history, with an impressive 8-0 on the road.

In injury news, the Patriots will be without running back TreVeyon Henderson due to an ankle injury, while the Seahawks will miss safety Ty Okada (hamstring).

The latest betting odds show the Seahawks as 3-point favorites, with an over/under of 44.5 points. Emory Hunt, a CBS Sports HQ analyst, enters the season with a strong 28-16 record on picks involving the Seahawks, returning $1,047 to $100 players.

Key Betting Lines:

• Spread: Seahawks -3
• Over/Under: 44.5 points
• Money Line: Seahawks -174, Patriots +146

Hunt predicts a lean towards the Under 44.5 combined points, citing both teams' robust defenses from the previous season. The Seahawks ranked sixth in total yards allowed (285.6 per game) and gave up the fewest points (17.2). Defensive standout Ernest Jones IV led with 126 tackles and five interceptions. Meanwhile, New England finished eighth in total yards allowed (295.2) and fourth in points allowed (18.8), with linebacker Robert Spillane recording 97 tackles and two interceptions.

For further insights and expert picks, visit SportsLine.